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@media(max-width:1080px){main{padding:30px 4% 0}.site-header{padding:0 4%;height:72px}.scope-card{width:270px;padding:19px}.intro{gap:25px}.metric{padding:19px 16px}.filter-field{width:170px}.endpoint-field{width:115px}.workbench{grid-template-columns:minmax(0,1.1fr) minmax(0,1fr)}.panel-heading{padding:0 14px}.detail-section,.detail-hero{padding-left:16px;padding-right:16px}.measurement-table th:first-child,.measurement-table td:first-child{padding-left:14px}.results-footer{padding-left:14px;padding-right:14px;flex-wrap:wrap}.results-footer span:last-child{display:none}}
@media(max-width:850px){.intro{align-items:flex-start}.scope-card{width:245px}.intro-copy{font-size:13px}.metrics{grid-template-columns:repeat(2,1fr)}.metric:nth-child(3){border-left:0;border-top:1px solid var(--line)}.metric:nth-child(4){border-top:1px solid var(--line)}.metric strong{font-size:27px}.filters{flex-wrap:wrap;gap:10px}.search-field{flex-basis:100%}.filter-field{flex:1;width:auto}.endpoint-field{max-width:170px}.checkbox-label{padding:0 6px}.workbench{grid-template-columns:1fr}.table-wrap{max-height:430px}.evidence-panel{border-left:0;border-top:1px solid var(--line)}.evidence-panel .empty-state{min-height:200px}.detail-hero,.detail-section{padding:20px}.value-strip{max-width:460px}.source-table th{min-width:80px}.measurement-table th:first-child{width:36%}.measurement-table td{padding-top:13px;padding-bottom:13px}.results-footer span:last-child{display:block}.source-table-wrap{max-width:100%}}
@media(max-width:580px){main{padding:25px 18px 0}.site-header{height:65px;padding:0 18px}.brand{font-size:19px;gap:8px}.brand-mark{width:29px;height:29px}.header-meta{font-size:0;gap:0}.status-dot{display:none}.tag{font-size:11px;margin:0}.intro{display:block;margin-bottom:23px}.eyebrow{font-size:10px;letter-spacing:1.5px}.intro h1{font-size:28px;letter-spacing:-1px}.intro-copy{font-size:13px;line-height:1.7;margin-top:14px}.scope-card{width:100%;margin-top:20px;padding:15px 17px}.scope-label{font-size:10px;margin-bottom:8px}.scope-card strong{font-size:13px}.scope-species{font-size:13px;margin-top:3px}.scope-bottom{margin-top:11px;padding-top:10px;font-size:11px;gap:15px}.metric{padding:16px 14px}.metric-label{font-size:12px}.metric strong{font-size:25px;margin-top:5px}.metric-note{font-size:11px}.review-notice{font-size:12px;padding:11px;gap:8px}.explorer{margin-top:27px}.section-heading .eyebrow{font-size:10px;letter-spacing:1px}.section-heading{margin-bottom:18px;align-items:flex-end}h2{font-size:19px}.button{font-size:12px;padding:9px 11px}.button svg{width:13px;height:13px}.filters label:not(.checkbox-label){font-size:11px}.filters .filter-field{flex:1;max-width:none}.checkbox-label{flex-basis:100%;height:25px;font-size:12px;padding:0}.measurement-table th{font-size:10px;padding-left:5px;padding-right:5px}.measurement-table td{padding-left:5px;padding-right:5px;font-size:12px}.measurement-table th:first-child{width:35%}.measurement-table th:nth-child(3){width:31%}.measurement-table th:last-child{width:8%}.compound-button{font-size:13px}.paper-id{font-size:10px}.measurement-kind,.unit-cell{font-size:11px}.review-badge{font-size:10px}.panel-heading{height:50px}.panel-step{font-size:10px}.results-footer{font-size:10px}.detail-hero,.detail-section{padding:17px}.detail-title{font-size:20px}.value-number{font-size:16px}.source-title{font-size:13px}.site-footer{font-size:10px;padding-top:19px;gap:4px}.site-footer>span{width:100%}}
@media(prefers-reduced-motion:reduce){*{scroll-behavior:auto!important;animation:none!important;transition:none!important}}
.review-badge.is-reviewed{color:var(--c1f6b52);background:var(--ce3f1e8)}
.scope-why{font-size:13px;line-height:1.6;color:var(--muted);margin-top:10px}.scope-why:empty{display:none}
.target-chips{display:flex;flex-wrap:wrap;gap:8px;margin-bottom:16px}
.target-chip{display:inline-flex;align-items:center;gap:7px;border:1px solid var(--ccad6d3);background:var(--surface);color:var(--ink);border-radius:999px;padding:7px 13px;font-size:13px;font-weight:600;cursor:pointer}
.target-chip:hover{border-color:var(--c92b5a6);background:var(--cf4f8f4)}
.target-chip[aria-pressed="true"]{background:var(--teal);border-color:var(--teal);color:var(--surface)}
.target-chip .chip-count{font-weight:500;opacity:.7;font-variant-numeric:tabular-nums}
.target-chip .chip-tag{font-size:11px;font-weight:700;letter-spacing:.3px;border-radius:4px;padding:2px 5px;background:var(--ce9f3ec);color:var(--c1f6b52)}
.target-chip[aria-pressed="true"] .chip-tag{background:var(--on-accent-soft);color:var(--surface)}
.paper-id .target-name{font-family:inherit;color:var(--c5f7376)}
.enzyme-field{width:260px}@media(max-width:850px){.enzyme-field{flex-basis:100%;width:auto}}
.source-field{width:200px}.source-tag{font-family:inherit;font-size:11px;font-weight:700;border-radius:4px;padding:1px 5px;margin-left:4px;background:var(--ceef0fb);color:var(--c3b4a9c)}
.chembl-note{font-size:12px;line-height:1.6;color:var(--c3b4a9c);background:var(--cf1f3fc);border-left:2px solid var(--c9aa6e0);padding:8px 10px;margin-top:10px}
.match-yes{color:var(--c1f6b52);font-weight:650}.match-no{color:var(--c9a7528);font-weight:650}
.cap-note{font-size:12px;color:var(--muted);padding:10px 19px;border-top:1px solid var(--line)}
@media(max-width:850px){.source-field{flex:1;width:auto}}
.structure-img{display:block;width:100%;max-width:260px;height:auto;background:var(--surface);border:1px solid var(--line);border-radius:6px;margin:4px 0 10px}
.identity-list{display:grid;grid-template-columns:80px 1fr;gap:6px;margin:8px 0 0;font-size:11px;line-height:1.5;color:var(--muted)}.identity-list dt{font-weight:600}.identity-list dd{margin:0;overflow-wrap:anywhere;font-family:ui-monospace,SFMono-Regular,Consolas,monospace}
/* ---- Polish layer ---------------------------------------------------------- */
:root{font-family:Inter,-apple-system,BlinkMacSystemFont,"Segoe UI",sans-serif;--mono:"JetBrains Mono",ui-monospace,SFMono-Regular,Consolas,monospace;--shadow:0 1px 2px rgba(20,45,58,.04),0 4px 16px rgba(20,45,58,.05);--chart-bar:#0f8a68;--chart-bar-hover:#0b6b51;--chart-marker:#b0452f}
@media (prefers-color-scheme:dark){:root:not([data-theme="light"]){--shadow:0 1px 2px rgba(0,0,0,.4);--chart-bar:#2e9d7c;--chart-bar-hover:#4fc09d;--chart-marker:#dd7053}}
:root[data-theme="dark"]{--shadow:0 1px 2px rgba(0,0,0,.4);--chart-bar:#2e9d7c;--chart-bar-hover:#4fc09d;--chart-marker:#dd7053}
body{-webkit-font-smoothing:antialiased;text-rendering:optimizeLegibility}
.site-header{position:sticky;top:0;z-index:5;background:color-mix(in srgb,var(--surface) 88%,transparent);backdrop-filter:saturate(1.4) blur(10px);-webkit-backdrop-filter:saturate(1.4) blur(10px)}
.paper-id,.provenance-details dd,.identity-list dd,.count-badge{font-family:var(--mono)}
.metrics,.workbench,.scope-card,.potency-panel{box-shadow:var(--shadow)}
.metric strong{font-feature-settings:"tnum" 1}
h1{letter-spacing:-1.6px}
.theme-toggle{margin-left:10px;border:1px solid var(--line);background:var(--surface);color:var(--muted);border-radius:999px;padding:5px 11px;font-size:11px;font-weight:600}
.theme-toggle:hover{color:var(--ink);border-color:var(--muted)}
.sort-button{all:unset;cursor:pointer;display:inline-flex;gap:4px;align-items:center;font:inherit;color:inherit}
.sort-button:hover{color:var(--ink)}.sort-button:focus-visible{outline:2px solid var(--teal);outline-offset:3px;border-radius:3px}
.potency-panel{position:relative;background:var(--surface);border:1px solid var(--line);border-radius:var(--radius);padding:16px 19px 8px;margin-bottom:17px}
.potency-head{display:flex;justify-content:space-between;align-items:baseline;gap:12px;flex-wrap:wrap;margin-bottom:6px}
.potency-head h3{font-size:13px}
.potency-note{font-size:12px;color:var(--muted)}
.potency-chart{width:100%;overflow:hidden}
.potency-svg .grid{stroke:var(--line);stroke-width:1;stroke-dasharray:2 3}
.potency-svg .baseline{stroke:var(--muted);stroke-width:1;opacity:.5}
.potency-svg .tick{stroke:var(--muted);opacity:.6}
.potency-svg .axis-label{font-size:11px;fill:var(--muted);font-variant-numeric:tabular-nums}
.potency-svg .bar{fill:var(--chart-bar)}
.potency-svg .bin:hover .bar{fill:var(--chart-bar-hover)}
.potency-svg .hit{fill:transparent;cursor:crosshair}
.potency-svg .marker{stroke:var(--chart-marker);stroke-width:2}
.potency-svg .marker-label{font-size:12px;font-weight:600;fill:var(--ink);paint-order:stroke;stroke:var(--surface);stroke-width:4px}
.chart-tip{position:absolute;top:40px;transform:translateX(-50%);pointer-events:none;background:var(--ink);color:var(--surface);border-radius:6px;padding:6px 9px;font-size:12px;line-height:1.4;display:flex;flex-direction:column;white-space:nowrap;box-shadow:var(--shadow)}
.chart-tip strong{font-weight:650}
@media(max-width:580px){.theme-toggle{margin-left:6px}.potency-panel{padding:12px 12px 6px}}
/* ---- Longevity lab theme ------------------------------------------------------ */
:root{--serif:"Instrument Serif",Georgia,"Times New Roman",serif;--accent:#a4531c;--grid-line:rgba(29,92,70,.06);--chart-bar:#1d6b4f;--chart-bar-hover:#14503a;--chart-marker:#b4581d}
@media (prefers-color-scheme:dark){:root:not([data-theme="light"]){--accent:#e39a62;--grid-line:rgba(127,207,166,.05);--chart-bar:#4aa983;--chart-bar-hover:#7fcfa6;--chart-marker:#e39a62}}
:root[data-theme="dark"]{--accent:#e39a62;--grid-line:rgba(127,207,166,.05);--chart-bar:#4aa983;--chart-bar-hover:#7fcfa6;--chart-marker:#e39a62}
body{background:var(--page)}
.site-header{border-bottom:1px solid var(--line)}
.brand{font-family:var(--serif);font-size:26px;letter-spacing:-.2px}.brand span{font-weight:400}.brand strong{font-style:italic;font-weight:400;color:var(--teal)}
.header-meta{font-family:var(--mono);font-size:11px;letter-spacing:.3px}
.tag{font-family:var(--mono);border-color:var(--accent);color:var(--accent)}
.status-dot{background:var(--accent);box-shadow:0 0 0 3px color-mix(in srgb,var(--accent) 20%,transparent)}
main{position:relative}
.intro{position:relative;display:grid;grid-template-columns:minmax(0,1.15fr) minmax(0,.85fr);gap:56px;align-items:center;padding:28px 0 36px;margin-bottom:28px}
.intro::before{content:"";position:absolute;inset:-44px -6vw 0;z-index:-1;background-image:linear-gradient(var(--grid-line) 1px,transparent 1px),linear-gradient(90deg,var(--grid-line) 1px,transparent 1px);background-size:28px 28px;-webkit-mask-image:linear-gradient(180deg,#000 55%,transparent);mask-image:linear-gradient(180deg,#000 55%,transparent)}
.eyebrow{font-family:var(--mono);text-transform:uppercase;letter-spacing:1.6px;font-weight:500;color:var(--accent)}
.intro h1{font-family:var(--serif);font-weight:400;font-size:clamp(40px,4.6vw,68px);line-height:1.02;letter-spacing:-1.2px;margin:0;max-width:14ch}
.intro h1 em{font-style:italic;color:var(--teal)}
.intro-copy{font-size:16px;line-height:1.65;max-width:560px;margin-top:22px;color:var(--muted)}
.intro-chips{display:flex;flex-wrap:wrap;gap:8px;margin-top:22px}
.intro-chips span{font-family:var(--mono);font-size:11px;padding:6px 10px;border:1px solid var(--line);border-radius:999px;background:var(--surface);color:var(--ink)}
.intro-side{display:flex;flex-direction:column;gap:14px;min-width:0}
.hero-art{margin:0;background:var(--surface);border:1px solid var(--line);border-radius:var(--radius);padding:14px 14px 10px;box-shadow:var(--shadow)}
.hero-art figcaption{font-size:11.5px;line-height:1.55;color:var(--muted);margin-top:6px}
.ha-grid line{stroke:var(--line);stroke-width:1}
.ha-half{stroke:var(--muted);stroke-dasharray:3 4;opacity:.7}
.ha-ic{stroke:var(--muted);stroke-dasharray:2 3;opacity:.45}
.ha-curve{fill:none;stroke-width:2.2;stroke-linecap:round}
.ha-curve.c1{stroke:var(--accent)}.ha-curve.c2{stroke:var(--teal)}.ha-curve.c3{stroke:var(--muted)}
.ha-dots circle{stroke:var(--surface);stroke-width:2}
.ha-dots.c1{fill:var(--accent)}.ha-dots.c2{fill:var(--teal)}.ha-dots.c3{fill:var(--muted)}
.ha-label,.ha-ic-label{font-family:var(--mono);font-size:10px;fill:var(--muted)}.ha-ic-label{fill:var(--accent);font-weight:500}
.hero-art .ha-curve{stroke-dasharray:600;stroke-dashoffset:600;animation:draw 1.6s ease-out forwards}.hero-art .ha-curve.c2{animation-delay:.25s}.hero-art .ha-curve.c3{animation-delay:.5s}
.hero-art .ha-dots{opacity:0;animation:fade .5s ease-out 1.2s forwards}
@keyframes draw{to{stroke-dashoffset:0}}@keyframes fade{to{opacity:1}}
.scope-card{width:auto;background:var(--surface);border:1px solid var(--line);border-left:3px solid var(--accent);border-radius:var(--radius);padding:16px 18px}
.scope-label{font-family:var(--mono);text-transform:uppercase;letter-spacing:1.4px;color:var(--accent)}
.scope-card strong{font-family:var(--serif);font-weight:400;font-size:24px;line-height:1.15}
.scope-species{font-family:var(--mono);font-size:11px}
.metrics{background:var(--surface);border-color:var(--line)}
.metric-label{font-family:var(--mono);text-transform:uppercase;letter-spacing:1px;font-size:10.5px;font-weight:500}
.metric strong{font-family:var(--serif);font-weight:400;font-size:44px;letter-spacing:-.5px;line-height:1.1}
.benchmark strong{color:var(--teal)}
.review-notice{background:var(--amber-soft);border-color:color-mix(in srgb,var(--accent) 25%,transparent)}
h2{font-family:var(--serif);font-weight:400;font-size:34px;letter-spacing:-.4px}
.detail-title{font-family:var(--serif);font-weight:400;font-size:30px;letter-spacing:-.2px}
.potency-head h3{font-family:var(--serif);font-weight:400;font-size:22px}
.potency-note{font-family:var(--mono);font-size:11px}
.workbench,.potency-panel{background:var(--surface);border-color:var(--line)}
.measurement-table th{font-family:var(--mono);text-transform:uppercase;letter-spacing:.8px;font-size:10px;background:color-mix(in srgb,var(--page) 60%,var(--surface))}
.compound-button{font-weight:600}
.button-primary{background:var(--teal)}
.site-footer{font-family:var(--mono);font-size:10.5px}
@media(max-width:1080px){.intro{grid-template-columns:1fr;gap:28px}.intro-side{flex-direction:row;align-items:stretch}.hero-art{flex:1.2}.scope-card{flex:1}}
@media(max-width:700px){.intro-side{flex-direction:column}.intro h1{font-size:40px}.metric strong{font-size:32px}h2{font-size:28px}}
@media(prefers-reduced-motion:reduce){.hero-art .ha-curve{animation:none;stroke-dashoffset:0}.hero-art .ha-dots{animation:none;opacity:1}}
.brand{white-space:nowrap}.intro h1{max-width:17ch}
@media(max-width:700px){.header-meta .meta-text{display:none}.brand{font-size:22px}.site-header{height:64px}.intro{padding:12px 0 20px;margin-bottom:16px}.header-meta{font-size:0}.header-meta .tag,.header-meta .theme-toggle{font-size:11px}.status-dot{display:none}}
html,body{overflow-x:clip}

/* Keep the evidence workspace close to the introduction. */
.intro{padding:8px 0 20px;gap:28px;margin-bottom:16px;grid-template-columns:minmax(0,1.5fr) minmax(0,.7fr)}
.intro h1{font-size:clamp(32px,3.4vw,48px);max-width:24ch}
.intro-copy{margin:12px 0;font-size:15px;line-height:1.5;max-width:680px}
.intro-chips{margin-top:12px}.hero-art{display:none}.explore-link{display:inline-block;margin-top:4px}
.chart-guidance{font-size:12px;line-height:1.5;color:var(--muted);margin:10px 0 16px}
@media(max-width:1080px){.intro{grid-template-columns:1fr}.intro-side{display:none}}
@media(max-width:700px){.intro{gap:12px;padding:8px 0 12px}.intro h1{font-size:32px}.intro-copy{font-size:14px}.intro-chips{display:none}.metrics{margin-bottom:14px}}

/* Compact hero, but keep the IC50 explainer on wide screens and the enzyme card everywhere. */
.intro{grid-template-columns:minmax(0,1.35fr) minmax(0,.9fr)}
.hero-art{display:block;padding:10px 12px 8px}.hero-art svg{max-height:170px}.hero-art figcaption{font-size:11px;margin-top:2px}
@media(max-width:1080px){.intro-side{display:flex;flex-direction:column}.hero-art{display:none}}

.nav-links{display:flex;gap:18px;margin-right:18px;font-size:13px;font-weight:600}.nav-links a{color:var(--muted);text-decoration:none}.nav-links a[aria-current]{color:var(--ink)}.nav-links a:hover{color:var(--ink)}@media(max-width:580px){.nav-links{gap:12px;margin-right:8px;font-size:12px}}
@media(max-width:420px){.site-header{gap:10px}.brand{gap:6px}.brand>span{font-size:14px}.brand-mark{width:24px;height:24px}.tag{display:none}.header-meta .nav-links{gap:9px;margin-right:0}.theme-toggle{margin-left:6px;padding:4px 8px}}